789 Identification of amino acid residues in ABCC6 important for substrate interaction
نویسندگان
چکیده
منابع مشابه
Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity.
Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage occurs between a specific alanine or glycine residue (depending on the procollagen chain) and an invariant aspartic acid residue in each of the three chain...
متن کاملIdentification of amino acid residues important for assembly of GABAA receptor a1 and c2 subunits
Comparative models of GABAA receptors composed of a1b3c2 subunits were generated using the acetylcholinebinding protein (AChBP) as a template and were used for predicting putative engineered cross-link sites between the a1 and the c2 subunit. The respective amino acid residues were substituted by cysteines and disulfide bond formation between subunits was investigated on co-transfection into hu...
متن کاملIdentification of Amino Acid Residues Important for Ligand Binding to Fas
The interaction of Fas (CD95), a member of the tumor necrosis factor receptor (TNFR) family, and its ligand (FasL) triggers programmed cell death (apoptosis) and is involved in the regulation of immune responses. Although the Fas-FasL interaction is conserved across species barriers, little is currently known about the molecular details of this interaction. Our aim was to identify residues in F...
متن کاملIdentification of amino acid residues important in the cyclization reactions of chalcone and stilbene synthases.
Chalcone synthase (CHS) and stilbene synthase (STS) catalyse condensation reactions of p-coumaroyl-CoA and three C(2) units from malonyl-CoA up to a common tetraketide intermediate but then catalyse different cyclization reactions to produce naringenin chalcone and resveratrol respectively. On the basis of sequence alignment with other condensing enzymes including 3-ketoacyl-(acyl carrier prote...
متن کاملImportant amino acid residues of potato plant uncoupling protein (StUCP).
Chemical modifications were used to identify some of the functionally important amino acid residues of the potato plant uncoupling protein (StUCP). The proton-dependent swelling of potato mitochondria in K(+)-acetate in the presence of linoleic acid and valinomycin was inhibited by mersalyl (K(i) = 5 microM) and other hydrophilic SH reagents such as Thiolyte MB, iodoacetate and 5, 5'-dithio-bis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.799